Background:

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.

Applications:

ELISA, IHC

Name of antibody:

WNK4

Immunogen:

Synthetic peptide of human WNK4

Full name:

WNK lysine deficient protein kinase 4

Synonyms:

PHA2B; PRKWNK4

SwissProt:

Q96J92

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

25-100